Efficacy and Safety of Lipid-Lowering Drugs as Primary and Secondary Prevention of Cardiovascular Diseases in the Elderlyin the Uzbekistan
DOI:
https://doi.org/10.51699/ijcm.v13i.197Keywords:
elderly, hypercholesterolemia, lipid-lowering therapyAbstract
Management Cardiovascular diseases (CVD) are the leading cause of death worldwide. It is predicted that by 2030 .the number of deaths due to CVD will increase to 23.3 million per year [1]. The prevalence of CVD and its risk factors increases as the population's life expectancy increases [2]. According to the American Heart and Stroke Associations (American Heart Association and American Stroke Association), coronary heart disease (CHD), heart failure, stroke, hypertension, or a combination of these diseases occur in 69.1% of men and 67.9% of women aged 60-79 years and 84.7% and 85.9% over 80 years, respectively [3]. The first heart attack develops on average at the age of 65.0 years in men and 71.8 years in women, and is mainly associated with the presence of atherosclerotic lesions of the coronary bed [3]. The vast majority (about 80%) of people dying from CVD associated with atherosclerosis are people over the age of 65 [4]. In France, people aged 85 years and older account for 43% of deaths from CHD, and 49% from stroke [5]. The effect of hyperlipidemia on morbidity and mortality in elderly patients is considered. The article also highlights the effectiveness and safety of lipid-lowering agents in the primary and secondary prevention of cardiovascular diseases in patients ≥80 years of age, which are the fastest growing population group and have the highest cardiovascular risk. It emphasizes the need to take into account polymorbidity and polypharmacy of risk-increasing adverse reactions caused by both statins themselves and their drug interactions, which requires an assessment of the risk/benefit ratio. In addition, it is necessary to develop reliable tools for predicting relevant outcomes (for example, stroke, disability, reduced quality of life) and evaluating the rationality of lipid-lowering therapy in elderly patients, as well as their adherence to treatment.
References
World Health Organization. Global status report on noncommunicable diseases. WHO: Geneva; 2010.
Hamilton-Craig I, Colquhoun D, Kostner K, et al. Lipid-modifying therapy in the elderly. Vasc Health Risk Manag 2015;11:251-63.
Mozaffarian D, Benjamin EJ, Go AS, et al. American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Heart Disease and Stroke Statistics—2015 Update: a report from the American Heart Association. Circulation 2015;131: e29-e322.
Jacobson TA, Maki KC, Orringer CE3, et al. National Lipid Association Recommendations for Patient Centered Management of Dyslipidemia: Part 2. J Clin Lipidol 2015;9(6 Suppl):S1-122e1.
Alpérovitch A, Kurth T, Bertrand M, et al. Primary prevention with lipid lowering drugs and long term risk of vascular events in older people: population based cohort study. BMJ 2015;350:h2335. Bukhara State Medical Institute, Bukhara, Uzbekistan
Nutfilloevich K. O. LIPID METABOLISM DISORDERS IN CHRONIC ALCOHOL INTOXICATION //Ижтимоий Фанларда Инновация онлайн илмий журнали. – 2022. – Т. 2. – №. 1. – С. 187-190.
Nutfilloevich K. O. ALCOHOL ABUSE AMONG GASTROENTEROLOGICAL PATIENTS PROFILE INFORMATION // Ижтимоий Фанларда Инновация онлайн илмий журнали – 2022. – Т. 2. – №. 1. – С. 94-100.
Navruzov R. R. Morphofunctional Forms of Lymphoid Structures the Index of the Colon is Normal and When Exposed to A Biostimulator Against the Background of Radiation Sickness //Middle European Scientific Bulletin. – 2021. – Т. 16.
Navruzov R. R. Morphofunctional Lymphoid Structures of the Colon in Normal and Under the Influence of Radiation Sickness //" ONLINE-CONFERENCES" PLATFORM. – 2021. – С. 63-64.
Mashrabovna I. I. Relapses of Differentiated Thyroid Cancer //European Journal of Life Safety and Stability (2660-9630). – 2021. – Т. 7. – С. 70-75.
Искандарова И. М. и др. Рецидивы дифференцированного рака щитовидной железы //Барқарорликва Етакчи Тадқиқотлар онлайн илмий журнали. – 2021. – Т. 1. – №. 6. – С. 134-150.
Мелибоева Ш. Ш., БолтаевМ. М., Шарипова Э. М. Сравнительная Эффективность Препарата «Нодинорм» При Комплексном Лечении Фиброзно-Кистозной Мастопатии //CENTRAL ASIAN JOURNAL OF MEDICAL AND NATURAL SCIENCES. – 2021. – С. 114-119.
Meliboyeva S. et al. Quantitative determination thymol in syrup" Kalinol plus" of the HPLC method. – 2016.
Мухаммедова З. Р., Болтаев М. М. «TINCTURAMORUS»-КЛАДЕЗЬ ВИТАМИНОВ И МИНЕРАЛЬНЫХ ВЕЩЕСТВ АКТУАЛЬНАЯ В ПЕРИОД ПАНДЕМИИ COVID-19 //Новый день в медицине. – 2020. – №. 4. – С. 726-730.
Бондарева И. В., Бондарєва І. В., Болтаев М. Исследование мотивации на эффективность работы специалистов фармации. – 2019.
Харибова Е. А., Тешаев Ш. Ж. Морфофункциональные особенности тканевой организации энтероэндокринных клеток в возрастном аспекте //Проблемы биологии и медицины. – 2020. – №. 2. – С. 168-173.
Харибова Е. А. Особенности морфологии нейрональных ансамблей в тройничном узле человека //Морфология. – 2011. – Т. 140. – №. 5. – С. 123-124.
Khodzhaeva D. I. Changes in the Vertebral Column and Thoracic Spinecells after Postponement of Mastoectomy //International Journal of Innovative Analyses and Emerging Technology. – 2021. – Т. 1. – №. 4. – С. 109-113.
Ilkhomovna K. D. Modern Look of Facial Skin Cancer //БарқарорликваЕтакчиТадқиқотларонлайнилмийжурнали. – 2021. – Т. 1. – №. 1. – С. 85-89.
Ilkhomovna K. D. Morphological Features of Tumor in Different Treatment Options for Patients with Locally Advanced Breast Cancer //International Journal of Innovative Analyses and Emerging Technology. – 2021. – Т. 1. – №. 2. – С. 4-5.
Khodjayeva D. I. MORPHOLOGY OF IDIOPATHIC SCOLIOSIS BASED ON SEGMENT BY SEGMENT ASSESSMENT OF SPINAL COLUMN DEFORMITY //Scientific progress. – 2022. – Т. 3. – №. 1. – С. 208-215.
Ходжаева Д. И. СОВРЕМЕННЫЕ ВОЗМОЖНОСТИ УЛЬТРАЗВУКОВОЙ ДИАГНОСТИКИ ПРИ РАКЕ КОЖИ ЛИЦА //Жизнеобеспечение при критических состояниях. – 2019. – С. 111-112.
Aslonov S. G. et al. Modern Approaches to Oropharyngeal Cancer Therapy //International Journal of Discoveries and Innovations in Applied Sciences. – 2021. – Т. 1. – №. 3. – С. 38-39.
Khodjaeva D. I. MAGNETIC-RESONANCE IMAGING IN THE DIAGNOSIS OF BREAST CANCER AND ITS METASTASIS TO THE SPINAL COLUMN //Scientific progress. – 2021. – Т. 2. – №. 6. – С. 540-547.
Тиллоева Ш. Ш. и др. Estimation of the condition of the cardiorespiratory system of patients with the concilation of bronchial asthma and arterial hypertension, effects of complex therapy //Новыйдень в медицине. – 2020. – №. 2. – С. 227-230.
Tillaeva S. S. et al. Currency and diagnostic criteria of rheumatoid arthritis in patients of senior age groups //Asian Journal of Multidimensional Research (AJMR). – 2018. – Т. 7. – №. 11. – С. 184-188.
Тиллоева Ш. Ш. и др. Estimation of the condition of the cardiorespiratory system of patients with the concilation of bronchial asthma and arterial hypertension, effects of complex therapy //Новыйдень в медицине. – 2020. – №. 2. – С. 227-230.
Тиллоева Ш. Ш., Давлатов С. С. Эффективность И Переносимость Локсидола В Лечение Ревматоидного Артрита У Пациентов Старших Возрастных Групп //CENTRAL ASIAN JOURNAL OF MEDICAL AND NATURAL SCIENCES. – 2021. – С. 432-436.
Тиллоева Ш. Ш., Бозоров А. С., Раджабов Р. К. Трансфузиологии. НовыеРекомендацииПоПереливаниюЭритроцитов //CENTRAL ASIAN JOURNAL OF MEDICAL AND NATURAL SCIENCES. – 2021. – С. 418-422.
Султонова Н. А. ИНДИВИДУАЛЬНЫЙ ПОДХОД К ПРОГНОЗИРОВАНИИЮ САМОПРОИЗВОЛЬНЫХ ВЫКИДЫШЕЙ У ЖЕНЩИН ДО 24 НЕДЕЛЬ ГЕСТАЦИИ //Современные вызовы для медицинского образования и их решения. – 2021. – С. 406.
Sultonova N. A. Treatment of hypercoagulable conditions in women with misscarriage in early gestation //Asian Journal of Multidimensional Research (AJMR). – 2020. – Т. 9. – №. 12. – С. 13-16.
Адизова Д. Р., Адизова С. Р., Иброхимова Д. Б. Место депрессивных расстройств у пациенток с хронической сердечной недостаточностью //Биология и интегративная медицина. – 2021. – №. 4 (51). – С. 79-90.
Adizova D. R. et al. Rational approach to standard therapy //Central Asian Journal of Pediatrics. – 2019. – Т. 2. – №. 2. – С. 49-53.
