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Efficacy and Safety of Lipid-Lowering Drugs as Primary and Secondary Prevention of Cardiovascular Diseases in the Elderlyin the Uzbekistan

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Abstract

Management Cardiovascular diseases (CVD) are the leading cause of death worldwide. It is predicted that by 2030 .the number of deaths due to CVD will increase to 23.3 million per year [1]. The prevalence of CVD and its risk factors increases as the population's life expectancy increases [2]. According to the American Heart and Stroke Associations (American Heart Association and American Stroke Association), coronary heart disease (CHD), heart failure, stroke, hypertension, or a combination of these diseases occur in 69.1% of men and 67.9% of women aged 60-79 years and 84.7% and 85.9% over 80 years, respectively [3]. The first heart attack develops on average at the age of 65.0 years in men and 71.8 years in women, and is mainly associated with the presence of atherosclerotic lesions of the coronary bed [3]. The vast majority (about 80%) of people dying from CVD associated with atherosclerosis are people over the age of 65 [4]. In France, people aged 85 years and older account for 43% of deaths from CHD, and 49% from stroke [5]. The effect of hyperlipidemia on morbidity and mortality in elderly patients is considered. The article also highlights the effectiveness and safety of lipid-lowering agents in the primary and secondary prevention of cardiovascular diseases in patients ≥80 years of age, which are the fastest growing population group and have the highest cardiovascular risk. It emphasizes the need to take into account polymorbidity and polypharmacy of risk-increasing adverse reactions caused by both statins themselves and their drug interactions, which requires an assessment of the risk/benefit ratio. In addition, it is necessary to develop reliable tools for predicting relevant outcomes (for example, stroke, disability, reduced quality of life) and evaluating the rationality of lipid-lowering therapy in elderly patients, as well as their adherence to treatment.

Keywords

elderly
hypercholesterolemia
lipid-lowering therapy

Declarations

Conflict of Interest Statement

The author (s) declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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Cite this article as:

Midkhatovna, S. E. . (2022). Efficacy and Safety of Lipid-Lowering Drugs as Primary and Secondary Prevention of Cardiovascular Diseases in the Elderlyin the Uzbekistan. International Journal of Culture and Modernity, 13, 68–75. Retrieved from https://ijcm.academicjournal.io/index.php/ijcm/article/view/197
  • Submitted
    16 February 2022
  • Revised
    16 February 2022
  • Published
    16 February 2022